Direct answer: A UPS cargo aircraft crashed shortly after takeoff from Louisville Muhammad Ali International Airport in Kentucky. It was an MD-11 freighter en route to Honolulu, and the incident resulted in multiple fatalities and injuries, with the airport closing and surrounding areas issuing shelter-in-place orders as responders managed a large fire and debris field. Investigations by the NTSB and FAA are ongoing. Details and context:

• Aircraft: UPS Airlines MD-11F (three crew aboard) that was departing Louisville and headed to Honolulu when it went down and erupted into a fireball. Initial reports indicated significant fuel on board and a violent impact near the airport. [web results indicate UPS MD-11 awareness and flight details; sources describe the aircraft type and departure incident].

• Location and impact: The crash occurred just south of the airfield, with a substantial fire affecting nearby structures and prompting closures of the airport and surrounding roads. Shelter-in-place advisories were issued for areas near the scene..

• casualties and status: Early reports indicated fatalities and injuries, with numbers varying across outlets as the situation developed; multiple outlets reported at least seven deaths and numerous injuries by the evening of the event, with authorities updating as investigations continued..

• Response and investigation: Local authorities, state officials, and federal agencies (FAA and NTSB) coordinated a response, with the NTSB dispatching investigators to the scene to determine the cause. The FAA reported the incident and airport closure, while ongoing investigations will detail contributing factors..

If you’d like, I can pull the latest updates from reputable outlets to confirm the current casualty count and any official preliminary findings, and summarize the confirmed facts from those sources.