According to multiple sources, the state with the most Powerball jackpot winners is Indiana, with 39 wins since 1992. The other states with the most Powerball jackpot winners are Missouri with 31 wins, Minnesota with 22 wins, Pennsylvania and Wisconsin with 19 wins each, and Kentucky with 18 wins. Its important to note that not all states participate in the Powerball lottery, and some states have never sold a jackpot-winning ticket for either Powerball or Mega Millions.