Statins are usually taken once a day. The timing depends on the type of statin: short-acting statins are generally best taken in the evening, while long-acting statins can be taken at any time of day as long as they are taken consistently at the same time each day. For example:

• Short-acting statins like simvastatin, lovastatin, and fluvastatin are typically recommended at night because cholesterol production peaks at night.
• Long-acting statins such as atorvastatin (Lipitor) and rosuvastatin (Crestor) can be taken in the morning or evening without compromising effectiveness.

Taking statins consistently is critical for their effectiveness, and they can usually be taken with or without food. It is best to follow the specific advice of a healthcare provider about when to take the statin. If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose—do not double up doses.