The best time to take folic acid is flexible—it can be taken in the morning, at night, or any time of day. For optimal absorption, it should be taken on an empty stomach with plenty of water before a meal. Some sources suggest taking it in the morning since digestion slows at night, which may help with better absorption and avoid any potential interference with sleep due to B vitamin effects. However, if stomach upset occurs, taking it at night or at a time that feels better is also acceptable. The key is consistency in taking it daily rather than the specific time of day.

Key points on taking folic acid:

• Take folic acid with plenty of water on an empty stomach before meals for best absorption.
• Morning is generally recommended by many nutritionists due to better digestion and absorption.
• It can be taken any time of day if that suits the person's routine or to avoid stomach upset.
• Avoid taking it late at night if sensitive to B vitamins’ potential stimulating effects.
• Consistency in daily intake is more important than exact timing.

This advice applies broadly whether folic acid is taken for general supplementation or prenatal reasons to support healthy pregnancy outcomes.