Jonathan Taylor is out due to a high ankle sprain he suffered in Week 4 during the Colts' win over the Steelers. This injury affects the same ankle that has troubled him in previous seasons, including significant setbacks in 2022 and 2023. The Colts have been cautious with his recovery, and Taylor has missed multiple games since the injury. While he is optimistic about returning, he has not practiced yet, and his return timeline remains uncertain as he continues to work on regaining full mobility and the ability to perform the cuts and explosive movements required for his position. The Colts have been managing his absence by using other running backs like Trey Sermon and Tyler Goodson.