The main cast of the TV series "Why Women Kill" includes:

• Ginnifer Goodwin as Beth Ann Stanton
• Lucy Liu as Simone Grove
• Kirby Howell-Baptiste as Taylor Harding
• Alexandra Daddario as Jade
• Sam Jaeger as Rob Stanton
• Jack Davenport as Karl Grove
• Reid Scott as Eli Cohen
• Sadie Calvano as April

The series spans different time periods and follows the complex lives of these characters, focusing on the motivations behind why women kill in response to betrayal and infidelity in their relationships.