Hepatitis B vaccine is typically given as a 3-dose series at 0, 1, and 6 months for most children and adults, providing long-term protection.

Standard Schedules

The primary schedule follows a 0, 1, and 6-month timeline, with the first dose often at birth for infants to ensure early protection. Minimum intervals require dose 2 at least 4 weeks after dose 1 and dose 3 at least 8 weeks after dose 2 and 16 weeks after dose 1. Alternative accelerated options exist, such as a 4-dose series for faster immunity (doses at 0, 7, 21-30 days, and 12 months).

Options by Age and Type

• Infants : Birth dose within 24 hours, then 1 and 6 months.

• Adults 18+ (Heplisav-B) : 2-dose series, one month apart—no boosters needed.

• Combination (Twinrix, adults only) : 4 doses at 0, 7, 21-30 days, and 12 months for hepatitis A and B protection.

Once the full series is completed, no routine boosters are required for sustained immunity. Consult a healthcare provider for personalized advice based on risk factors or prior vaccination.